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UK MHRA Guidance: The Advisory Committee on Borderline Substances: How to Submit an Application (Updated 20 March 2026)

This guidance, "Submitting an application for review by the ACBS," explains how to submit an application to the Advisory Committee on Borderline Substances (ACBS). The ACBS evaluates products that may be considered borderline between foods and medicines, particularly for use within the NHS. The guidance provides a structured approach to ensure that applications are complete, accurate, and suitable for review.


Purpose of the Application Process

The purpose of this guidance is to help applicants understand how to prepare and submit a valid application for ACBS consideration.

It ensures that:

  • Products are assessed consistently

  • Relevant clinical and nutritional evidence is provided

  • Decision-making is transparent and evidence-based

  • Applicants follow a standardised submission process

Complete an Application Form

As outlined in this guidance, applicants must complete the required application form before submission.

The application form should include:

  • Product details and composition

  • Intended use and target patient population

  • Clinical evidence supporting use

  • Nutritional information

  • Proposed indications and positioning

All information must be clear, accurate, and supported by appropriate evidence, as incomplete applications may delay the review process.

Send an Application

This guidance explains that once the application form is completed, it must be submitted through the appropriate channel as specified.

Applicants should ensure that:

  • All required documents are included

  • Supporting evidence is properly referenced

  • The submission meets formatting and completeness requirements

Proper submission ensures that the application can be reviewed without unnecessary delays.

ACBS Meetings and Submission Closing Dates

According to this guidance, ACBS reviews applications during scheduled meetings held throughout the year.

Applicants must be aware of:

  • Submission deadlines for each meeting cycle

  • Timelines for review and feedback

  • The importance of submitting applications well in advance

Missing submission deadlines may result in delays, as applications will be considered in the next available meeting.

Importance of Following the Process

As highlighted in this guidance, following the correct submission process is essential for efficient evaluation.

It helps to:

  • Ensure timely review of applications

  • Reduce the risk of rejection due to incomplete information

  • Support evidence-based decision-making

  • Facilitate access to appropriate products within the NHS

📌 Reference

For full details, refer to the official  guidance: Submitting an application for review by the ACBS

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